changes of the uterine tissue in rats with polycystic ovary syndrome induced by estradiol valerate
نویسندگان
چکیده
objective: : polycystic ovary syndrome (pcos) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. in this study, the effect of pcos induction was studied using estradiol valerate. materials and methods: adult female wistar rats weighing approximately 200 gr were divided into control, sham, and experimental groups (n=6). in the experimental group, pcos was induced using subcutaneous injection of 2 mg estradiol valerate. for histological and cytological studies, after the approval of syndrome induction, the rats in all groups were dissected and their uterus was removed and fixed. the uterine tissue sections were, then, stained with h&e; and iron- hematoxylin methods. factors like height of the epithelium, thickness of the uterus wall, and frequency of the mitotic cells were examined. the data were assessed at α=0.05. results: findings the study of uterine tissue revealed that the height of the uterus luminal epithelium, the thickness of the uterus wall and the frequency of eosinophils in the endometrial stroma were increased significantly in the experimental group. in addition, the frequency of mitotic cells in the experimental group was increased in both luminal and glandular epithelia of the uterus. the increasing rate of the glandular epithelium region was noticeable and significant. conclusion: the results indicate that induction of polycystic ovary syndrome by estrdiol valerate could change the proliferation rate in the endometrial tissue of the uterus.
منابع مشابه
Changes of The Uterine Tissue in Rats With Polycystic Ovary Syndrome Induced by Estradiol Valerate
Objective : Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. Reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. In this study, the effect of PCOS induction was studied using estradiol valerate. MaterialsAndMethods Adult ...
متن کاملChanges of The Uterine Tissue in Rats with Polycystic Ovary Syndrome Induced by Estradiol Valerate
BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. Reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. In this study, we assess the effect of PCOS induction by estradiol valerate (EV) in a rat model. MATERIALS ...
متن کاملHistochemical study of estradiol valerate-induced polycystic ovary syndrome in the rat
For the present study, and follow-up of histochemical changes in estradiol valerate-induced polycysticovary syndrome (PCOS), 48 virgin 90-day-old female rats were used. The rats were divided into thetreatment and control groups. For each rat of the treatment group, 4 mg estradiol valerate was injectedthrough intramuscular route for the induction of PCOS. The control group was taken the same amo...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملhistochemical study of estradiol valerate-induced polycystic ovary syndrome in the rat
for the present study, and follow-up of histochemical changes in estradiol valerate-induced polycysticovary syndrome (pcos), 48 virgin 90-day-old female rats were used. the rats were divided into thetreatment and control groups. for each rat of the treatment group, 4 mg estradiol valerate was injectedthrough intramuscular route for the induction of pcos. the control group was taken the same amo...
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عنوان ژورنال:
international journal of fertility and sterilityجلد ۱۱، شماره ۱، صفحات ۴۷-۵۴
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